Planta Med 2003; 69(2): 130-134
DOI: 10.1055/s-2003-37707
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Honokiol Ameliorates Cerebral Infarction from Ischemia-Reperfusion Injury in Rats

Kuo-Tong Liou1 , Su-Man Lin2 , Shiang-Suo Huang3 , Chun-Lien Chih2 , Shen-Kou Tsai3
  • 1Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • 2Department of Anesthesiology, National Yang-Ming University School of Medicine and Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
  • 3Department of Anesthesiology, College of Medicine, National Taiwan University and National Yang-Ming University, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C
Weitere Informationen

Publikationsverlauf

Received: June 17, 2002

Accepted: September 22, 2002

Publikationsdatum:
07. März 2003 (online)

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Abstract

Honokiol, a constituent extracted from Magnolia officinalis, had been shown be an antioxidant and an anti-platelet agent in biological systems with an anti-arrhythmic effect and a myocardial protective effect on ischemia-reperfusion injury. We examined the neuroprotective effect of honokiol in rats subjected to focal cerebral ischemia. Honokiol was administered intravenously either at fifteen minutes before right middle cerebral artery occlusion (pretreatment groups) or when both common carotid arteries clips were removed (treatment groups). The results showed that there was no significant hemodynamic change after intravenous infusion of honokiol at the dosages of 10 - 8, 10 - 7 and 10 - 6 g/kg in both groups. However, honokiol significantly reduced the total volume of infarction at the doses of 10 - 7 or 10 - 6 g/kg in both pretreatment and treatment groups. This study suggests that honokiol is a potent neuroprotective agent in focal cerebral ischemia. This beneficial effect may be related to its antioxidant effect and anti-platelet aggregation activity.

References

Professor Shen-Kou Tsai

National Taiwan University and National Yang-Ming University and Taipei Veterans General Hospital

201 Shih-Pai Road, Section 2

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