Abstract
A diastereoselective multicomponent synthesis of highly functionalized
imidazolines is reported. A silicon mediated 1,3 dipolar cycloaddition
of the in situ generated münchnone with an imine resulted
in the formation of highly substituted imidazolines. The imidazolines
contain a four-point diversity and two stereocenters and the cycloaddition
reaction is applicable to aryl, alkyl, acyl, and heterocyclic substitutions.
Key words
imidazolines - 1,3-dipolar cycloaddition - diastereoselective - heterocycles - imidazoles
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