Efficient Conversions of Carboxylic Acids into O-Alkyl, N-Alkyl and O,N-Dialkylhydroxamic Acids

Alan R. Katritzky; Nataliya Kirichenko; Boris V. Rogovoy

doi:10.1055/s-2003-42488

PAPER

Efficient Conversions of Carboxylic Acids into O-Alkyl, N-Alkyl and O,N-Dialkylhydroxamic Acids

Alan R. Katritzky*, Nataliya Kirichenko, Boris V. Rogovoy
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Fax: +1(352)3929199; e-Mail: Katritzky@chem.ufl.edu;

Abstract

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Abstract

Carboxylic acids were conveniently converted into unsubstituted, N-alkyl-, O-alkyl-, and O,N-dialkylhydroxamic acids via acylbenzotriazole intermediates. The ready availability of the reagents, mild conditions, and easy handling of the intermediates are advantageous.

Key words

hydroxamic acid - Weinreb amide - carboxylic acids - regioselectivity - nucleophilic

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References

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