Planta Med 2003; 69(10): 947-950
DOI: 10.1055/s-2003-45106
Letter
© Georg Thieme Verlag Stuttgart · New York

Saucernetin-7 and Saucernetin-8 Isolated from Saururus chinensis Inhibit the LPS-induced Production of Nitric Oxide and Prostaglandin E2 in Macrophage RAW264.7 Cells

Hee-Juhn Park1 , Ryung-Gue Kim2 , Bo-Rim Seo2 , Joohun Ha3 , Byung-Tae Ahn4 , Song-Hae Bok4 , Yong Sup Lee5 , Hyoung Ja Kim5 , Kyung-Tae Lee2
  • 1Division of Applied Plant Sciences, Sangji University, Wonju, Korea
  • 2College of Pharmacy, Kyung Hee University, Seoul, Korea
  • 3College of Medicine, Kyung Hee University, Seoul, Korea
  • 4Cardiovascular Research laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon, Korea
  • 5Division of Life Sciences, KIST, Seoul, Korea
This research was supported by a grant (PF002104-07) from the Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government
Further Information

Publication History

Received: March 9, 2003

Accepted: July 26, 2003

Publication Date:
02 December 2003 (online)

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Abstract

In the present study, we demonstrate that saucernetin-8 (1) and saucernetin-7 (2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Both compounds 1 and 2, known as dineolignans, also suppressed the expression of iNOS and COX-2 protein in a dose-dependent manner. Thus, this study suggests that compounds 1 and 2-mediated inhibition of iNOS and COX-2 expression may be one of the mechanisms responsible for the anti-inflammatory effects of the underground parts of Saururus chinensis.

References

Dr. Kyung-Tae Lee

Department of Biochemistry

College of Pharmacy

Kyung-Hee University

Dongdaemun-Ku

Hoegi-Dong 130-701

Seoul

Korea

Phone: +82-2-9610860

Fax: +82-2-9663885

Email: ktlee@khu.ac.kr