Microwave-Assisted Michael Addition of Some Pyrimidine and Purine Nucleobases with α,β-Unsaturated Esters: A Rapid Entry into Carboacyclic Nucleoside Synthesis

Abstract

An efficient procedure for the synthesis of some carbo­acyclic nucleosides via microwave-assisted Michael addition of various nucleobases to α,β-unsaturated esters in the presence of tetra­butylammonium bromide (TBAB) and DABCO is described. Using this method, some pyrimidine and purine nucleobases have been alkylated regioselectively in moderate to high yields and short reaction time.

carboacyclic nucleosides - microwave - Michael addition - nucleobases - α,β-unsaturated esters

References

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