Evaluation of the Anti-Inflammatory and Antioxidant Activities of Di-C-glucosylflavones from Lychnophora ericoides (Asteraceae)

Abstract

The Brazilian medicinal plant Lychnophora ericoides is commercially available as an analgesic and anti-inflammatory agent. The phytochemical investigation of the leaf polar extract yielded 6,8-di-C-β-glucosylapigenin (1) and the new compound 6,8-di-C-β-glucosylchrysin (2). 6,8-Di-C-β-glucosylapigenin (1) showed significant anti-inflammatory activity in the carrageenan-induced rat paw edema. We did not observe any statistical difference between the two compounds (1 and 2) in inhibiting chemiluminescence in opsonized zymosan-stimulated polymorphonuclear leukocytes, suggesting that the anti-inflammatory property of 6,8-di-C-β-glucosylapigenin (1) is not related to its antioxidant activity.

Key words

Lychnophora ericoides - Asteraceae - anti-edematogenic activity - C-glycosylflavones - 6,8-di-C-β-glucosylchrysin - vicenin-2

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