Planta Med 2005; 71(1): 87-89
DOI: 10.1055/s-2005-837759
Letter
© Georg Thieme Verlag KG Stuttgart · New York

In vitro Protein Tyrosine Phosphatase 1B Inhibitory Phenols from the Seeds of Psoralea corylifolia

Youn-Chul Kim1 , 3 , Hyuncheol Oh2 , 3 , Beom Seok Kim2 , Tai-Hyun Kang1 , Eun-Kyoung Ko1 , Yu Mi Han2 , Bo Yeon Kim2 , Jong Seog Ahn2
  • 1Phytofermentation Research Center and College of Pharmacy, Wonkwang University, Iksan, South Korea
  • 2Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea
  • 3These authors contributed equally to the work
Further Information

Publication History

Received: June 23, 2004

Accepted: October 14, 2004

Publication Date:
27 January 2005 (online)

Abstract

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.

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Dr. Jong Seog Ahn

Korea Research Institute of Bioscience and Biotechnology (KRIBB)

52 Eoeun-dong

Yusong

Daejeon 305-333

Korea

Fax: +82-42-860-4595

Email: jsahn@kribb.re.kr