The First Synthesis of Cynandione A

Abstract

Cynandione A was prepared from acetylbenzoquinone by conjugate addition, acylation and demethylation.

cynandione A - acetylbenzoquinone - conjugate addition - acylation - demethylation

References

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We assign the structure of the monoacetate based on the mass spectral fragmentation of M - H₂O, which we believe arises from the interaction between the acetyl group and the hydroxyl on the neighboring ring (Figure [2] ). This fragmentation is also observed in compounds 4, 5 and 1.

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