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Synthesis 2005(11): 1817-1821  
DOI: 10.1055/s-2005-865338
PAPER
© Georg Thieme Verlag Stuttgart · New York

Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Amino­pyrimidines from a Stable Precursor

Cyril B. Dousson, Nicola M. Heron, George B. Hill*
Cancer and Infection Research Area, AstraZeneca Healthcare, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Fax: +44(1625)513910; e-Mail: george.b.hill@astrazeneca.com;
Further Information

Publication History

Received 9 February 2005
Publication Date:
25 April 2005 (online)

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Abstract

An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vin­amidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks.

Key words

heterocycles - pyrimidines - condensation - amidine - vinamidinium

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1

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