Antimicrobial Azaphilones from the Fungus Hypoxylon multiforme

Abstract

Four new azaphilones named multiformins A - D together with a known compound 4 : 5:4′:5′-tetrahydroxy-1 : 1′-binaphthyl were isolated from the methanolic stromatal extract of the xylariaceous ascomycete Hypoxylon multiforme. Their absolute structures were characterised by 2D-NMR, UV, IR, mass and CD spectroscopy. Multiformins A - D showed strong and apparently non-selective antimicrobial activity.

Key words

Azaphilone - fungus - antimicrobial - multiformin - Hypoxylon multiforme

References

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