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Synthesis 2006(3): 425-434
DOI: 10.1055/s-2006-926282
DOI: 10.1055/s-2006-926282
PAPER
© Georg Thieme Verlag Stuttgart · New York
Two-Step Synthesis of N-Sulfonyl Aziridines from Epoxides
Further Information
Received
18 July 2005
Publication Date:
11 January 2006 (online)
Publication History
Publication Date:
11 January 2006 (online)
Abstract
A convenient and high-yielding two-step synthesis of N-sulfonyl aziridines starting from epoxides is described. The method, which involves epoxide ring opening with sulfonamides and subsequent mesylation-cyclisation, is particularly suitable for variation of the N-sulfonyl substituent; 18 examples are presented.
Key words
epoxides - ring opening - sulfonamides - aziridines
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