Planta Med 2006; 72(8): 767-770
DOI: 10.1055/s-2006-941505
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Phenanthrenes from the Rhizomes of Tamus communis

Borbála Réthy1 , Adriána Kovács2 , István Zupkó1 , Peter Forgo3 , Andrea Vasas2 , György Falkay1 , Judit Hohmann2
  • 1Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
  • 2Department of Pharmacognosy, University of Szeged, Szeged, Hungary
  • 3Department of Organic Chemistry, University of Szeged, Szeged, Hungary
This work is dedicated to Professor Kálmán Szendrei on the occasion of his 70th birthday
Further Information

Publication History

Received: January 6, 2006

Accepted: April 16, 2006

Publication Date:
19 June 2006 (online)

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Abstract

From the fresh rhizomes of Tamus communis five phenanthrenes (1 - 5) were isolated under the guidance of cytotoxic assays in HeLa cells. The compounds were obtained from the highly active CHCl3 fraction of the MeOH extract by using multistep chromatographic purifications, including VLC, preparative TLC, HPLC and gel filtration. The compounds were identified by means of EI-mass, UV and NMR spectroscopy as 7-hydroxy-2,3,4-trimethoxyphenanthrene (1), 2,7-dihydroxy-3,4-dimethoxyphenanthrene (nudol) (2), 2,7-dihydroxy-3,4,8-trimethoxyphenanthrene (3), 3,7-dihydroxy-2,4,8-trimethoxyphenanthrene (confusarin) (4), and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (5). Compound 1 is a new natural product, and 2 - 4 were isolated for the first time from T. communis. In the cytotoxic assays, compounds 1 - 3 and 5 significantly inhibited the growth of HeLa cells (IC50 = 0.97 - 20.18 μM). Compound 3, with an IC50 value of 0.97 μM, is of special interest because of its high activity.

References

Prof. Dr. Judit Hohmann

Department of Pharmacognosy

University of Szeged

Eötvös u. 6

6720 Szeged

Hungary

Phone: +36-62-546-453

Fax: +36-62-545-704

Email: hohmann@pharma.szote.u-szeged.hu