Abstract
A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane
(PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines.
These reactions tend to be quick (30 min), high-yielding, and tolerate a range of
other functional groups. Replacement of PMHS/KF with triethylsilane allows for the
reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending
on the substrate, both conditions can allow for the in situ conversion of the product
amines into amides, sulfonamides, and carbamates.
Key words
reduction - amines - nitro compounds - palladium - silicon hydride - hydroxylamines
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