Stereoselective Synthesis of meso- and cis-2,6-Diarylpiperidin-4-ones Catalyzed by l-Proline

Fernando Aznar; Ana-Belén García; Noelia Quiñones; María-Paz Cabal

doi:10.1055/s-2007-990814

PSP

Stereoselective Synthesis of meso- and cis-2,6-Diarylpiperidin-4-ones Catalyzed by l-Proline

Fernando Aznar*, Ana-Belén García, Noelia Quiñones, María-Paz Cabal
Unidad Asociada al C.S.I.C., Instituto Universitario de Química Organometálica ‘Enrique Moles’, Universidad de Oviedo, C/ Julián Clavería 8, 33006 Oviedo, Spain
Fax: +34(98)5103446; e-Mail: pcabal@uniovi.es;

Abstract

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Abstract

A convenient stereoselective preparation of meso- and cis-2,6-diarylpiperidin-4-ones has been developed by aza-Diels-Alder reaction catalyzed by l-proline from simple and commercially available starting materials.

Key words

2,6-diarylpiperidin-4-ones - organocatalysis - l-proline - aza-Diels-Alder - nitrogen heterocycles

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References

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