New Efficient Synthesis of Pyrido[2,3-c]coumarin Derivatives by Palladium-Catalyzed Heck Cyclization

Abstract

Tetrahydropyrido[2,3-c]coumarin derivatives were synthesized by intramolecular radical cyclization and Heck coupling. This method allowed the synthesis of the backbone of the Santi­agonamine alkaloid.

Key words

organometallic reagents - radical reactions - Heck coupling - intramolecular cyclization - 3-aminocoumarin

References

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For a detailed report on the toxicity of tin reagents, see: Occupational Exposure to Organotin Compounds, US Department of Health Education and Welfare: Washington D.C., Nov. 1976.