Total Syntheses of Phomallenic Acids B and C Utilizing Palladium-Catalyzed Coupling of Propargylic Tosylates with Terminal Alkynes

Abstract

Total syntheses of (±)-phomallenic acids B and C, potent FAS II inhibitors, have been achieved by a palladium-catalyzed coupling of propargylic tosylates and terminal alkynes. Attempts to find an enantiospecific coupling using optically active propargylic compounds resulted in racemization of the products.

alkynes - allene - coupling - palladium - phomallenic acid

References

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