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Synfacts 2008(3): 0287-0287
DOI: 10.1055/s-2008-1042683
DOI: 10.1055/s-2008-1042683
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Boron-Based Reagent for Enantioselective Reduction of Ketones
S. Eagon, J. Kim, K. Yan, D. Haddenham, B. Singaram*
University of California, Santa Cruz, USA
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
Boron-derived reducing agents used for reduction of carbonyls represent a vast group of common reagents used in organic synthesis. Although several examples of boron-based enantioselective reduction have been reported, many of those methodologies still suffer from great difficulties. Described here is a highly stable and effective boron reagent for highly efficient enantioselective reduction of ketones.