DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 57 · January 2019 DOI: 10.1055/s-008-42145

35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)

Heidelberg, 22.–23.02.2019
Kongresspräsident: Prof. Dr. Ralf Bartenschlager


P5.2
Alvarez-Silva, C; Schierwagen, R; Pohlmann, A; Magdaleno, F; Uschner, FE; Ryan, P; Vehreschild, MJGT; Claria, J; Latz, E; Lelouvier, B; Arumugam, M; Trebicka, J: Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
P5.3
Bender, S; Gillich, N; Reuter, A; Mutz, P; Oleksiuk, O; Dächert, C; Binder, M; Bartenschlager, R: Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
P5.6
Dächert, C; Schweinoch, D; Kaderali, L; Binder, M: Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma
P5.7
P5.10
Ehrlich, S; Wild, K; Smits, M; Zoldan, K; Hofmann, M; Thimme, R; Boettler, T: Type I Interferons promote maintenance and function of follicular T helper cells in vitro
P5.12
Schumacher, N; Müller, M; Gandraß, M; Lücke, K; Wunderlich, T; Lotter, H; Gagliani, N; Mittrücker, HW; Rehman, A; Rose-John, S; Schmidt-Arras, D: A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
P5.13
Hendricks, L; Hermanussen, L; Giersch, K; Volz, TK; Allweiss, L; Lohse, AW; Sureau, C; Casey, J; Dandri, M; Lütgehetmann, M: Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
P5.14
Hinrichsen, H; Klinker, H; Stoehr, A; John, C; Heyne, R; Klausen, G; Simon, KG; Cornberg, M; Kuhn, M; Naumann, U; Bilzer, M; Guenther, V; Witte, V; Zeuzem, S: High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
P5.15
Ibidapo-obe, O; Stengel, S; Köse, N; Stallmach, A; Bauer, M; Bruns, T: Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
P5.17
Kallin, N; Bosch, M; Manske, K; Donakonda, S; Wohlleber, D; Knolle, PA: Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
P5.19
Klopp, A; Philip, B; Pulé, M; Protzer, U; Wisskirchen, K: Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
P5.20
König, V; Manske, K; Kurz, S; Steiger, K; Knolle, PA; Wohlleber, D: Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
P5.21
Kunzmann, L; Schocknecht, T; Poch, T; Kauer, L; Kriz, M; Stein, S; Grewe, I; Preti, M; Hartl, J; Pannicke, N; Peiseler, M; Sebode, M; Weiler-Normann, C; Zenzusi, R; Carambia, A; Lohse, AW; Herkel, J; Schramm, C; Schwinge, D: Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
P5.22
P5.23
Lempp, FA; Sakin, V; Nkongolo, S; Schnitzler, P; Wedemeyer, H; Gal, FL; Gordien, E; Yurdaydin, C; Urban, S: A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
P5.25
Manske, K; Schneider, A; Ko, C; Steiger, K; Protzer, U; Knolle, PA; Wohlleber, D: Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
P5.28
Oberhardt, V; Karimzadeh, H; Kiraithe, M; Salimi Alizei, E; Bockmann, JH; Schulze zur Wiesch, J; Budeus, B; Hoffmann, D; Wedemeyer, H; Rodríguez-Frías, F; Casillas, R; Buti, M; Smedile, A; Alavian, SM; Heinold, A; Emmerich, F; Panning, M; Gostick, E; Price, DA; Timm, J; Hofmann, M; Raziorrouh, B; Thimme, R; Protzer, U; Roggendorf, M; Neumann-Haefelin, C: Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
P5.31
Piecha, F; Gänssler, JM; Pischke, S; Wehmeyer, MH; Laschtowitz, A; Röder, C; Lohse, AW; Schulze zur Wiesch, J: Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
P5.32
Piecha, F; Gänssler, JM; Wehmeyer, MH; Felden, J von; Laschtowitz, A; Röder, C; Jordan, S; Pischke, S; Lohse, AW; Schulze zur Wiesch, J: Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
P5.33
Piecha, F; Rickert, A; Wehmeyer, MH; Laschtowitz, A; Felden, J von; Röder, C; Bockmann, JH; Pischke, S; Lohse, AW; Schulze zur Wiesch, J: Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
P5.34
Raabe, J; Krämer, B; Lutz, P; Goeser, F; Finnemann, C; Hoffmeister, C; To Vinh, M; Kaiser, K; Manekeller, S; Branchi, V; van Bremen, T; Ludwig-Portugall, I; Strassburg, CP; Spengler, U; Abdallah, AT; Nattermann, J: Human intrahepatic ILC3 may modulate hepatic stellate cell activation
P5.35
Riedl, T; Reisinger, F; Lucifora, J; Neuhaus, K; Prokosch, S; Durantel, D; Dejardin, E; Heikenwälder, M: Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
P5.36
Rosenblatt, M; Teusel, M; Schilling, M; Klingmüller, U; Timmer, J: Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
P5.37
Rufinatscha, K; Stindt, S; Ehlting, C; Bartenschlager, R; Häussinger, D; Bode, JG: Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
P5.38
Rüschenbaum, S; Ciesek, S; Queck, A; Widera, M; Schwarzkopf, K; Brüne, B; Welsch, C; Zeuzem, S; Weigert, A; Lange, C: Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
P5.39
Schakat, M; Bovensiepen, C; Wöstemeier, A; Sebode, M; Lohse, AW; Schramm, C; Herkel, J; Weiler-Normann, C: Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
P5.40
Schelbert, S; Dries, V; Drebber, U; Schindeldecker, M; Weinmann, A; Bartenschlager, R; Schirmacher, P; Roth, W; Straub, BK: Lipid droplets and associated proteins in viral hepatitis
P5.41
Schnieders, A; Lickei, H; Manns, MP; Maasoumy, B; Hardtke, S; Cornberg, M; Kraft, ARM: Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
P5.42
Smits, M; Zoldan, K; Ishaque, N; Gu, Z; Fauvelle, C; Neumann-Haefelin, C; Baumert, T; Emmerich, F; Hofmann, M; Conrad, C; Thimme, R; Boettler, T: Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
P5.44
Tabata, K; Paul, D; Brügger, B; Superti-Furga, G; Bartenschlager, R: Identification of host cell factors involved in hepatitis C virus replication
P5.45
To Vinh, M; Krämer, B; Dobrikova, K; Gotter, C; Raabe, J; Hoffmeister, C; Kaiser, K; Finnemann, C; Wilhelm, C; Schmitt, V; Schwarze-Zander, C; Rockstroh, J; Strassburg, CP; Spengler, U; Nattermann, J: Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
P5.46
Tu, T; Zehnder, B; Levy, M; Micali, G; Tran, L; Dabere, O; Main, N; Shackel, N; Urban, S: Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
P5.47
Twu, WI; Tabata, K; Paul, D; Bartenschlager, R: Role of autophagy in hepatitis C virus replication
P5.48
Usman, Z; Karimzadeh, H; Protzer, U; Roggendorf, M; Frishman, D: HDVdb: Hepatitis D virus database
P5.49
Usman, Z; Mijočević, H; Karimzadeh, H; Al-Mahtab, M; Bazinet, M; Frishman, D; Vaillant, A; Roggendorf, M: Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
P5.52
Wandrer, F; Liebig, S; Schlue, J; Manns, MP; Schulze-Osthoff, K; Bantel, H: Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
P5.54
Wild, K; Jacobi, F; Smits, M; Zoldan, K; Flecken, T; Lang, J; Ehrenmann, P; Emmerich, F; Hofmann, M; Neumann-Haefelin, C; Thimme, R; Boettler, T: Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
P5.55
Winkler, F; Hensel, N; Wieland, D; Villa, M; Ishaque, N; Conrad, C; Pearce, EL; Thimme, R; Hofmann, M; Bengsch, B: Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
P5.56
Wisskirchen, K; Kah, J; Malo, A; Asen, T; Volz, TK; Allweiss, L; Wettengel, J; Urban, S; Lütgehetmann, M; Bauer, T; Dandri, M; Protzer, U: T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
P5.58
Zhang, Z; Trippler, M; Real, CI; Werner, M; Kemper, T; Treckmann, J; Paul, A; Baba, HA; Gerken, G; Wedemeyer, H; Schlaak, J; Lu, M; Broering, R: Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes