DOI: 10.1055/s-00000131

Synfacts

Issue 04 · Volume 15 · April 2019 DOI: 10.1055/s-009-42698

Synform

A48
Zanda, Matteo: SYNFORM ISSUE 2019/04

Synthesis of Natural Products and Potential Drugs

z0333
All PDFs of this category
0333
Synthesis of an HIV-1 Integrase Allosteric Site Inhibitor
0334
Synthesis of Paspaline A and Emindole PB
0335
Synthesis of Eburnane-Type Alkaloids
0336
Synthesis of (+)-Dysoline
0337
Synthesis of Atuveciclib
0338
Synthesis of a Glucokinase Activator
0339
Synthesis of Gefitinib
0340
Asymmetric Total Synthesis of (+)-Laurallene
0341
Asymmetric Synthesis of Netarsudil
0342
Synthesis of 2′-Fluoro-6′-methylene-carbocyclic Adenosine (FMCA)
0343
Syntheses of Δ12-Prostaglandin J Natural Products
0344
Synthesis of LX2761
0345
Synthesis of (+)-Pleurocins A and B
0346
Synthesis of (±)-Estrone

Synthesis of Heterocycles

z0347
All PDFs of this category
0347
Three-Component Synthesis of Quinazolinones
0348
New Biocatalytic Synthesis of Caprolactone by Oxidative Lactonization
0349
Organocatalytic Synthesis of Enantioenriched Five- and Six-Membered Cyclic Ureas
0350
Synthesis of Indolo[1,2-α]indole Derivatives by Gold(I)-Catalyzed Cycloisomerization
0351
Gold Carbene Route to Several Classes of Azaheterocycles
0352
Photodecarboxylative Azidation of Cyclic Amino Acids with Rhodamine 6G
0353
Palladium(II)-Catalyzed Activation for Nucleophilic Substitution Reactions
0354
Cobalt-Catalyzed Synthesis of Quinolines and Acridines from Anthranils
0355
Spiroindolines by Visible-Light-Mediated Intramolecular Cycloadditions
0356
Synthesis of Pyrrolophenanthridine Alkaloids by the Schmidt Reaction
0357
Synthesis of 2-Aminopyrroles and Quinoline-Based Polyazaheterocycles
0358
Titanocene-Catalyzed Synthesis of Functionalized Ring-Fused Piperidines
0359
Electrochemical Synthesis of Fluorinated 2-Oxazolines
0360
Synthesis of Carbazoles and Indolines by Gold-Catalyzed Diels–Alder Reactions
0361
Synthesis of (5E)-5-(Iodomethylene)-1,3-selenazolidin-2-ones

Synthesis of Materials and Unnatural Products

z0363
All PDFs of this category
0363
A New Twist on Sydnones
0364
A Mechanically Stabilized Helical Chiral Macrocycle
0365
Thiophenes through Thiolates
0366
Copper-Catalyzed Oxidation of Siloxanes to Polar Siloxanes
0367
Open and Shut Synthesis of an Oligoparaphenylene Dual Nanohoop
0368
Stars Align for Liquid Crystals via a New Supramolecular Click Mechanism
0369
Mind the Gap: Finite Nanotubes with Periodic Wall Defects
0370
A Rare Example of a Retro Baeyer–Villiger Reaction
0371
Spontaneous CO2 Conversion into Polymeric Materials
0372
Loose Canon: Tunable Quiniodal Macrocycles with Canonical and Zwitterionic Ground States
0373
Copper-Mediated Homocoupling for Naphthotetraindole Synthesis
0374
Everybody Loves Pie: Nitrogen-Doped Pyrenes

Metals in Synthesis

z0375
All PDFs of this category
0375
Cyclohexane Desymmetrization via Rhodium-Catalyzed C–H Activation
0376
Iron(III)-Catalyzed Carbonyl-Olefin Metathesis of Aliphatic Ketones
0377
Enantioselective Arylative Trifluoromethylation of Alkenes
0378
Bimetallic Hydroaminomethylation of α-Olefins
0379
Nickel-Catalyzed Alkylation of Heterocycles
0380
Cross-Dehydrogenative Heteroarylation of Cyclic Amines
0381
Asymmetric C(sp3)–H Arylation Through a Hybrid Palladium Catalyst
0382
Asymmetric C(sp3)–H Amidation of Thioamides Catal-yzed by a CobaltIII/Chiral Carboxylic Acid Hybrid System
0383
Diastereoselective Formation of All-cis-(Multi)Fluorinated Piperidines
0384
Iron(II)-Catalyzed Alkyl Heck Coupling
0385
Enantioselective Iron-Catalyzed Couplings of Aldehydes and Alkenes
0386
Cobalt(III)-Catalyzed [4+2] Annulation
0387
Cobalt-Catalyzed [2+2] Cycloaddition
0388
Chromium-Catalyzed Asymmetric Allylation
0389
Synthesis of Fully Substituted Cyclopentenones
0390
Rhodium-Catalyzed Enantioselective Cyclopropanations
0391
Sequential meta-C–H/ipso-C–O Functionalization of Phenols via Directing-Group Strategy
0392
Copper-Catalyzed Remote Trifluoromethylation
0393
A New Late-Stage Defluorosilylation
0394
Catellani Reaction: Synthesis of o,o′-Disubstituted Vinylarenes
0395
Copper-Catalyzed Enantioselective Reduction of α,β-Unsaturated Esters
0396
Iridium-Catalyzed Three-Component Coupling Reaction
0397
Palladium-Catalyzed Dearomative Intermolecular [4+1] Spiroannulation by C(sp3)–H Activation
0398
Iridium-Catalyzed Asymmetric Allylic O-Alkylation of Ketones
0399
Iron-Catalyzed Carbon (sp2)–Carbon (sp2) Oxidative Homo-Coupling
0400
Molybdenum-Catalyzed Direct Amination of Boronic Acids
0401
Stereoselective Synthesis of anti-Isomers of γ-Boryl-Substituted Homoallylic Alcohols
0402
Enantioselective Aryl Transfer using Chiral Lithium Amido Aryl Zincates
0403
Dual Photoredox/Copper Catalysis for C–H Functionalizations
0404
Gold-Catalyzed Temperature-Controlled Divergent Hydroamination/Cycloaddition Cascade Reactions

Polymer-Supported Synthesis

z0405
All PDFs of this category
0405
Hydroamination of Terminal Alkynes on Gold Nanoclusters
0406
Selective Catalytic Hydrogenation of α,β-Unsaturated Aldehydes
0407
Oxidation of Alcohols on Thermoresponsive-Polymer-Supported TEMPO
0408
A3 Coupling Reactions on Green-Synthesized Gold Nanoparticles
0409
Palladium-Catalyzed Carbocyclization–Borylation of Enallenols
0410
Tandem Catalytic C–H Arylation/Suzuki–Miyaura Coupling
0411
Photocatalytic Coupling Reactions on a Mixed-Ligand Metal–Organic Framework
0412
Knoevenagel–Michael and Click Reactions on a Cu(II)/Natural Phosphate Catalyst
0413
Pd(II)-Complex-Catalyzed Mizoroki–Heck Reaction in γ-Valerolactone
0414
Synthesis of Pyranopyrazoles Using TiO2-Coated Fe3O4-Immobilized Tungstic Acid
0415
Palladium-Photocatalyzed Self-Condensation of Primary Amines
0416
Synthesis of 4H-Pyrimido[2,1-b]benzothiazoles with a Heterogeneous Cu(II) Catalyst
0417
Denitrative Cyclizations of β-Nitrostyrenes on Supported Pd Nanoparticles
0418
Synthesis of Benzimidazoles Promoted by Rh@PS

Organo- and Biocatalysis

z0419
All PDFs of this category
0419
Application of Chemoinformatics in Asymmetric Catalysis
0420
Asymmetric Enzymatic Aminohydroxylation of Styrenyl Olefins
0421
Directed Evolution Permits Heme-Protein-Catalyzed sp3-C–H Alkylation
0422
Asymmetric Synthesis of Trifluoromethylated Spirooxindole Lactones
0423
Asymmetric Synthesis of All-Carbon Spirocycles by a Stetter/Aldol Cascade
0424
Chiral Bifunctional Phase-Transfer Catalysts for Asymmetric Aminations
0425
Electrophilic Sulfenylation of Indoles by PIII/PV=O Catalysis
0426
NHC-Catalyzed Aza-Stetter Reaction of Aldimines To Give 3-Methylenechromanones
0427
Aminoxyl-Catalyzed Electrochemical Diazidation of Alkenes
0428
The Knoevenagel Condensation

Chemistry in Medicine and Biology

z0429
All PDFs of this category
0429
A Chemoselective Conjugation of Peptides with Electron-Rich (Hetero)Arenes
0430
Specific Functionalization of Cysteine and Lysine Using Dinitroimidazoles
0431
Late-Stage Functionalization of Complex Primary Sulfonamides via NHC Catalysis
0432
Application of Hemithioindigo Photoswitches in Photopharmacology
0433
Synthesis of Aglaroxin C Analogues for Hepatitis C Viral Infection Inhibition
0434
Synthesis of a cGAMP Analogue
0435
A Small Clickable and Photoconvertible Fluorophore
0436
Synthesis of AWZ1066S, an anti-Wolbachia Drug Candidate
0437
Pyrazolopyrimidines: Molecular Correctors for MALT1-Related Immune Defects
0438
Selective Targeting of p38 MAPK Isoforms Using PROTACs
0439
Synthesis of Human Interleukin-8 by Native Chemical Ligation
0440
Synthesis of a Fluorescent Probe for Cell Surface Phosphatidylserine
0441
Synthesis of ‘Stretched’ Isosteres of Saturated Nitrogen Heterocycles
0442
Targeting Zinc Homeostasis in Cancer
0443
A Glutathione-Labile Oligonucleotide Protecting Group

Peptide Chemistry

z0445
All PDFs of this category
0445
O-Glycosylation of Unprotected Peptides
0446
One-Pot Peptide Modifications Using the MeDbz Linker
0447
Synthesis of Free α-Amino Acids from 1,2-Diols
0448
Two-Step Strategy for Thioamide Bond Formation by Using an Ynamide
0449
Photoredox-Catalyzed α-Fluoro-α-Amino Acid Synthesis
0450
Photoredox Catalysis with Amino Acid- and Peptide-Derived Katritzky Salts
0451
Petasis Reaction for Late-Stage Functionalization of Peptides
0452
Photocatalytic Decarboxylative C(sp3)–H Alkylation of Glycine or Peptides
0453
Manganese-Catalyzed Synthesis of Acylic, Hybrid, and Stapled Peptides
0454
Palladium-Catalyzed Asymmetric Aminomethylation
0455
Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation

Flow Chemistry

z0457
All PDFs of this category
0457
Automated Titration of Organometallic Reagents in Continuous Flow
0458
Oxidation of Csp3–H Bonds in Flow Using Methyl(trifluoromethyl)dioxirane
0459
Continuous-Flow Chemoenzymatic Dynamic Kinetic Resolution of Amines
0460
Continuous-Flow Diazotization

Erratum

0461
Gong, T.-J; Hea, S.-J; Lu, X; Pi, J.-J; Fu, Y; Wang, X.-X: Defluorinative Alkylation using Redox-Active Esters
0461
Seidl, F J; Min, C; Lopez, J A; Burns, N Z: Regio- and Enantioselective Haloazidation of Allylic Alcohols