DOI: 10.1055/s-00000058

Planta Medica

Issue 02 · Volume 88 · February 2022 DOI: 10.1055/s-012-52733 Focus Issue Pyrrolizidine Alkaloids

Editorial

  • 97

    Editorial

    • Focus Issue Pyrrolizidine Alkaloids

    Reviews

  • 98
    Schrenk, Dieter; Fahrer, Jörg; Allemang, Ashley; Fu, Peter; Lin, Ge; Mahony, Catherine; Mulder, Patrick P.J.; Peijnenburg, Ad; Pfuhler, Stefan; Rietjens, Ivonne M.C.M.; Sachse, Benjamin; Steinhoff, Barbara; These, Anja; Troutman, John; Wiesner, Jacqueline:

    Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment–A Workshop Report

    Supporting Information (PDF)
  • 118
    Wiesner, Jacqueline:

    Regulatory Perspectives of Pyrrolizidine Alkaloid Contamination in Herbal Medicinal Products

  • 125
    Steinhoff, Barbara:

    Pyrrolizidine Alkaloid Contamination in Medicinal Plants: Regulatory Requirements and Their Impact on Production and Quality Control of Herbal Medicinal Products

  • 130
    Widjaja, Frances; Alhejji, Yasser; Rietjens, Ivonne M. C. M.:

    The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides

    Open Access
    Supporting Information (PDF)

    • Original Papers

  • 144
    Plaza, Alberto; Toner, Frank; Harris, James; Ottersbach, Peter; Roper, Clive; Mahony, Catherine:

    Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin

    • Biological and Pharmacological Activity

    Original Papers

  • 152
    Schäfer, Anima M.; Gilgen, Pierrine M.; Spirgi, Clara; Potterat, Olivier; Meyer zu Schwabedissen, Henriette E.:

    Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2

    Supporting Information (PDF)
  • 163
    Pradubyat, Nalinee; Giannoudis, Athina; Elmetwali, Taha; Mahalapbutr, Panupong; Palmieri, Carlo; Mitrpant, Chalermchai; Ketchart, Wannarasmi:

    1′-Acetoxychavicol Acetate from Alpinia galanga Represses Proliferation and Invasion, and Induces Apoptosis via HER2-signaling in Endocrine-Resistant Breast Cancer Cells

    Supporting Information (PDF)