New Terpenoids from the Corticioid Fungus Punctularia atropurpurascens and their Antimycobacterial Evaluation^{[ # ]}

Abstract

Chemical investigation of Punctularia atropurpurascens strain HM1 (Punctulariaceae), a corticioid isolated from a decorticated piece of Quercus bark collected in Bosque de Tlalpan, Mexico City, led to the isolation of a new drimane, 1-α-hydroxy-isodrimenine (1) and a new tetrahydroxy kauranol, 16-hydroxy-phlebia-nor-kauranol (2), together with the known N-phenylacetamide (3). Structures of all compounds were elucidated by spectroscopic and spectrometric methods, and the absolute configuration of 1 and 2 was confirmed via single-crystal X-ray crystallography. The isolated compounds showed modest antimycobacterial activity.

Key words

Punctularia atropurpurascens - corticioid - drimane - nor-kaurane - antitubercular activity - Punctulariaceae

^# Dedicated to Professor Dr. A. Douglas Kinghorn on the occasion of his 75th birthday.

Publication History

Received: 15 December 2021

Accepted after revision: 22 February 2022

Article published online:
30 March 2022

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