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DOI: 10.1055/a-2322-3741
Evaluation of Transiently O-6 Protected Guanosine Morpholino Nucleosides in PMO Synthesis
Gefördert durch: Department of Science and Technology New Delhi DST/TDT/TC/RARE/2022/10c2Gefördert durch: Science and Engineering Research Board TTR/2021/000044
Here we present a novel strategy to synthesize O-6 protected morpholino guanosine monomers by trimethylsilylethyl group, 1-(4-azido-phenyl) ethan-1-ol and para methoxy benzyl alcohol, respectively. The introduction of this protecting group increases the solubility of the morpholino nucleoside which is crucial during PMO synthesis. HPLC analysis shows trimethylsilylethyl protected monomer gives better coupling efficiency in PMO synthesis compared to regular one. Moreover the nonpolar nature of the O-6 protected monomer facilitated the guanosine rich PMO block in solution.
Publikationsverlauf
Eingereicht: 26. Februar 2024
Angenommen: 08. Mai 2024
Accepted Manuscript online:
08. Mai 2024
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