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Synthesis
DOI: 10.1055/a-2738-8145
DOI: 10.1055/a-2738-8145
Paper
The Sequential One-Pot Reaction of Isatylidene Malononitriles and 4-Hydrazinocoumarin: Metal Catalyst-Free and Efficient Access to Coumarin-Fused Spiro[diazepin-5,3′-oxindole]
Authors
Abstract
The synthesis of hybrid heterocycles (spiro and fused heterocycles) is a golden opportunity to access novel compounds with unique photophysical and pharmaceutical properties. Therefore, an efficient and metal catalyst-free procedure was designed to prepare novel coumarin-fused spiro[diazepin-5,3′-oxindole] derivatives through a three-component, sequential, one-pot reaction. This method involves the use of various isatin derivatives, malononitrile, and 4-hydrazinocoumarin. The significance of this method lies in the accessibility of the mentioned raw materials and easy purification of the products by filtering and washing with a solvent.
Keywords
Isatin - Malononitrile - 4-Hydrazinocoumarin - Isatylidene Malononitrile - Coumarin-fused Spiro[diazepin-5,3′-oxindole] - Spiro-oxindoles - [1,2]-Diazepines - Spiro[diazepin-5,3′-oxindole]Publication History
Received: 12 September 2025
Accepted after revision: 27 October 2025
Article published online:
21 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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