Cesium Effect: Metal- and Ligand-Free N-(Hetero)Arylation of Sulfoximines

Abstract

A metal- and ligand-free Cs₂CO₃-promoted protocol for the N-(hetero)aryl functionalization of sulfoximines. The synthetic methodology exhibits a broad substrate scope, and the mild reaction conditions enable the functionalization of chiral sulfoximines with complete retention of configuration.

Keywords

Nucleosides - Sulfoximines - Metal-free - Ligand-free - Heteroarenes

Publication History

Received: 19 August 2025

Accepted after revision: 27 October 2025

Article published online:
26 November 2025

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