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Planta Med 1960; 8(4): 411-419
DOI: 10.1055/s-0028-1101577
© Georg Thieme Verlag Stuttgart · New York

ZUM WIRKUNGSMECHANISMUS DES FLUORACETATS IM SÄURESTOFFWECHSEL VON ASPERGILLUS NIGER 1

R. Springer
  • Aus dem Institut für Pharmazie und Lebensmittelchemie der Universität München
1 Vorgetragen auf der 8. Vortragstagung der Deutschen Gesellschaft für Arzneipflanzenforschung in Braunschweig am 23.10.1960.
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Publication Date:
15 January 2009 (online)

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Summary

Monofluoracetic acid and trifluoracetic acid exsert a marked influence on growth and metabolism of Aspergillus niger.

Monofluoracetic acid inhibits strongly the accumulation of citric acid and of total acids. Oxalic acid and gluconic acid are accumulated predominantly if the mould is grown in the presence of monofluoracetic acid. The possible mechanisms of these metabolic shifts caused by monofluoracetic acid are discussed.

Trifluoracetic acid is much less toxic to Aspergillus niger and the metabolic disorders are different from those caused by monofluoracetic acid.