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Planta Med 1975; 28: 232-250
DOI: 10.1055/s-0028-1105799
© Georg Thieme Verlag Stuttgart · New York

NEUERE UNTERSUCHUNGEN ZUR BIOSYNTHESE EINIGER ANTIBIOTIKA

Recent Investigations on the Biosynthesis of some AntibioticsH. Grisebach
  • Lehrstuhl für Biochemie der Pflanzen der Universität Freiburg i. Br., 78 Freiburg i. Br.
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Publication Date:
14 January 2009 (online)

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Abstract

The large number of antibiotics can biogenetically be divided into 3 groups depending on the origin of their building units from amino acid, fatty acid or carbohydrate metabolism. Combinations of these pathways are also possible. Most of our knowledge on the biosynthesis of antibiotics stems from in vivo studies with isotopically labelled precursos. Only in a few cases has the enzymology been studied. Newer results on the biosynthesis of penicillins, cephalosporines, cyclic polypeptide antibiotics, ansamycins, and streptomycin are discussed.

Furthermore some examples are given for the regulation of antibiotic biosynthesis by catabolite repression.

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