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Synthesis 2009(12): 2040-2060  
DOI: 10.1055/s-0029-1216810
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Novel Structurally Simplified Estrogen Analogues with Electron-Donating Groups in Ring A

Lutz F. Tietze*, Carsten A. Vock, Ilga K. Krimmelbein, Linda Nacke
Institute of Organic and Biomolecular Chemistry, University of Goettingen, Tammannstr. 2, 37077 Goettingen, Germany
Fax: +49(551)399476; e-Mail: ltietze@gwdg.de;
Further Information

Publication History

Received 18 November 2008
Publication Date:
14 May 2009 (online)

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Abstract

A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction.

Key words

alkynes - estrogens - Corey-Fuchs reaction - Sonogashira reaction - steroids

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