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Synfacts 2009(11): 1300-1300
DOI: 10.1055/s-0029-1218071
DOI: 10.1055/s-0029-1218071
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Microwave-Assisted Sonogashira-Type Reaction Using Pd-EnCat
J. Sedelmeier, S. V. Ley*, H. Lange, I. R. Baxendale
University of Cambridge, UK
Further Information
Publication History
Publication Date:
22 October 2009 (online)
Significance
Microwave-assisted copper-free Sonogashira coupling was performed with the Ph3P-containing Pd-EnCatTM TPP30. The copper-free Sonogashira coupling of 4-bromoaceto-phenone (1) with phenylacetylene (2) was carried out in the presence of Pd-EnCatTM TPP30 (3) with the aid of microwave irradiation to give 1-[4-(phenylethynyl)phenyl]ethanone (4) in 98% yield. The catalyst was recovered and reused five times without any loss of catalytic activity.