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Synfacts 2009(11): 1285-1285
DOI: 10.1055/s-0029-1218108
DOI: 10.1055/s-0029-1218108
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Continuous-Flow Mannich Reactions Using a Solid-Supported Hydroxyproline
E. Alza, C. Rodríguez-Escrich, S. Sayalero, A. Bastero, M. A. Pericàs*
Institute of Chemical Research of Catalonia, Tarragona and Universitat de Barcelona, Spain
Further Information
Publication History
Publication Date:
22 October 2009 (online)
Significance
The authors developed a solid-supported hydroxyproline 1 which catalyzes the Mannich reaction of aldehydes and ketones with N-PMP-ethyl glyoxylate imine efficiently in high yields, diastereoselectivities, and enantioselectivities. For aldehydes the reaction was implemented in a flow system allowing continuous synthesis with a residence time of minutes and a fourfold reduction of catalyst with respect to the batch process.