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Synfacts 2010(1): 0082-0082  
DOI: 10.1055/s-0029-1218500
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Dicationic Pd(II)-Catalyzed Alkenylation of Glyoxylate with Vinylsilanes

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
K. Aikawa, Y. Hioki, K. Mikami*
Tokyo Institute of Technology, Japan
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

The authors described the enantio­selective alkenylation of glyoxylate with vinyl­silanes catalyzed by a chiral dicationic palladium BINAP complex. The desired allylic alcohols were obtained in good yields and excellent enantio­selectivities. Furthermore, they applied this method to dienylation and trienylation with excellent enantioselectivities.