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Synfacts 2010(4): 0479-0479  
DOI: 10.1055/s-0029-1219519
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Enantioselective Synthesis of Cyclic α-Amino Acids

Contributor(s): Benjamin List, Anna Lee
T. Kano, R. Sakamoto, H. Mii, Y. G. Wang, K. Maruoka*
Kyoto University, Japan
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

The authors report the catalytic enantioselective synthesis of cyclic α-alkyl amino acids using a chiral phase-transfer catalyst. Various cyclic amino acid derivatives having a tetrasubstituted α-carbon such as α-alkylprolines were obtained in good yields and excellent enantioselectivities via C,N-double alkylation.