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Planta Med 2012; 78(2): 189-192
DOI: 10.1055/s-0031-1280320
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells

Ke-Ke Li1 , Chun-Mei Yao1 , Xiu-Wei Yang1
  • 1State Key Laboratory of Natural and Biomimetic Drugs (Peking University), School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, P. R. China
Weitere Informationen

Publikationsverlauf

received July 30, 2011 revised October 8, 2011

accepted October 12, 2011

Publikationsdatum:
27. Oktober 2011 (online)

    Lizenzen und Reprints

Abstract

Four new triterpene saponins, ginsenosides Rh14-Rh17 (1–4), along with two known compounds, 20(S)-ginsenoside Rg2 and dammar-(E)-20(22),24-diene-3β,6α,12β-triol, were isolated from the stems and leaves of Panax ginseng. The structures of the new compounds were elucidated as 3β,6α,12β,24ξ-tetrahydroxy-dammar-(E)-20(22),25-diene 6-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (1), 3β,12β,24ξ-trihydroxy-dammar-(E)-20(22),25-diene 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (2), 3β,6α,12β-trihydroxy-dammar-(E)-20(22),24-diene 3-O-β-D-glucopyranoside (3), and 3-oxo-6α,12β,20(S)-trihydroxy-dammar-24-ene 6-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (4) by means of extensive spectroscopic and chemical methods, respectively. The isolated compounds were tested for in vitro cytotoxicity against HL-60 cells.

Key words

Panax ginseng - Araliaceae - dammarane triterpenoids - saponin - cytotoxicity - HL-60

Supporting Information

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Prof. Xiu-Wei Yang

State Key Laboratory of Natural and Biomimetic Drugs (Peking University)
School of Pharmaceutical Sciences
Peking University Health Science Center

38 Xueyuan Road, Haidian District

100191 Beijing

P. R. China

Telefon: +86 10 82 80 51 06

Fax: +86 10 82 80 27 24

eMail: xwyang@bjmu.edu.cn

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