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Synfacts 2011(11): 1181-1181
DOI: 10.1055/s-0031-1289236
DOI: 10.1055/s-0031-1289236
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New York
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D. Tejedor*, S. López-Tosco, J. González-Platas, F. García-Tellado*
Consejo Superior de Investigaciones Científicas, La Laguna, Instituto Canario de Investigación del Cáncer and Universidad de La Laguna, Spain
Further Information
Publication History
Publication Date:
19 October 2011 (online)
Significance
A variety of polysubstituted cyclohexadienones (2) can be accessed in high yield via the O-enolate-driven cyclization of skipped diynes 1. Reduction of 2 followed by deprotection affords highly functionalized biaryls 3. The substitution pattern present in 3a and 3b is difficult to access via other routes.