Synthesis and Properties of α-Bromomethyl-Substituted β-Ethoxyvinyl Polyfluoroalkyl Ketones

Abstract

An efficient and practical method for the synthesis of α-bromomethyl-substituted β-alkoxyvinyl polyfluoroalkyl ketones is reported. These highly functionalized α-bromomethyl enones easily react with various nucleophiles and binucleophiles affording a wide variety of new functionalized enones and heterocyclic systems that are perspective starting materials for the synthesis of compounds with potentially high biological and pharmacological activity.

Key words

enones - fluorine - halogenation - radical reaction - nucleophilic reaction - heterocycles

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