Potassium-Exchanged Zirconium Hydrogen Phosphate [α-Zr(KPO₄)₂]-Catalyzed Synthesis of 2-Amino-4H-pyran Derivatives under Solvent-Free Conditions

Abstract

A high-yielding, one-pot, three-component synthesis of functionalized 2-amino-4H-pyrans from β-dicarbonyl compounds, activated cyanomethylene compounds, and aldehydes, mediated by potassium-exchanged zirconium hydrogen phosphate [α-Zr(KPO₄)₂], is reported. The protocol shows excellent versatility, as it can be applied to aromatic, aliphatic, or α,β-unsaturated aldehydes under solvent-free conditions.

Key words

pyrans - amines - heterogeneous catalysis - solvent-free synthesis - multicomponent reactions - cyclizations

• References

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