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Am J Perinatol 2020; 37(06): 607-612
DOI: 10.1055/s-0039-1685446
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis

Guangliang Jia
1   Department of Rehabilitation Medicine, Changyi People's Hospital, Changyi, Shandong, China
,
Yanxiang Gao
2   Department of Cardiothoracic Surgery, Changyi People's Hospital, Changyi, Shandong, China
,
Chunzhi Li
3   Department of Infectious Disease, Changyi People's Hospital, Changyi, Shandong, China
,
Yanqin Zhang 
4   Department of Nursing, Yulin Traditional Chinese Medicine Hospital, Yulin, Shanxi, China
› Author Affiliations Funding None.
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Publication History

15 January 2019

28 February 2019

Publication Date:
16 April 2019 (online)

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Abstract

Objective Whether melatonin receptor 1B (MTNR1B) variants are implicated in gestational diabetes mellitus (GDM) remains unclear. Therefore, we performed this meta-analysis to obtain a more conclusive result on associations between MTNR1B variants and GDM.

Study Design Literature research was performed in PubMed, Web of Science, Embase, and China National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results A total of 17 studies were eligible for analyses. Pooled overall analyses showed that rs1387153 (dominant model: p = 0.0002, OR = 0.78, 95% CI: 0.68–0.89; recessive model: p < 0.0001, OR = 1.46, 95% CI: 1.24–1.73; allele model: p < 0.0001, OR = 0.78, 95% CI: 0.72–0.84), rs4753426 (recessive model: p = 0.01, OR = 1.75, 95% CI: 1.14–2.68; allele model: p = 0.01, OR = 0.69, 95% CI: 0.51–0.93), and rs10830963 (dominant model: p < 0.0001, OR = 0.72, 95% CI: 0.65–0.78; recessive model: p < 0.0001, OR = 1.56, 95% CI: 1.40–1.74; allele model: p < 0.0001, OR = 0.73, 95% CI: 0.69–0.78) variants were all significantly associated with the susceptibility to GDM. Further subgroup analyses by ethnicity of participants yielded similar positive results.

Conclusion Our findings indicated that MTNR1B rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM.

Keywords

melatonin receptor 1B - genetic variants - gestational diabetes mellitus - meta-analysis

Authors' Contributions

G.J. and Y.Z. conceived the study and participated in its design. G.J. and Y.G. conducted the systematic literature review. C.L. performed data analyses. G.J. and Y.Z. drafted the article. All authors gave final approval and agree to be accountable for all aspects of work ensuring integrity and accuracy.


Supplementary Material

Letter to this article:

Comments on “Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis”Am J Perinatol 2021; 38(03): 310-312
DOI: 10.1055/s-0039-1695777

 

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