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Synlett 2022; 33(13): 1273-1281
DOI: 10.1055/s-0040-1719929
DOI: 10.1055/s-0040-1719929
letter
Silver-Catalyzed, One-Pot, Three-Component Difunctionalization of Quinones: Synthesis of Indole-Functionalized p-Iminoquinone Derivatives
We are grateful for the financial support from the Chengdu Normal University Project (2021CS21ZCY02), the National undergraduate training program for innovation and entrepreneurship (Grant No. 202114389016 and 202114389005), and the Foundation of Chengdu Normal University Talent Introduction Research Funding (2021YJRC202020).
Abstract
A one-pot, three-component difunctionalization of quinones with indoles and arylamines has been developed to synthesize indole functionalized p-iminoquinones derivatives. The approach employed AgOAc as the catalyst in the presence of 3-chlorophenylboronic acid, giving a series of indole functionalized p-iminoquinones derivatives in moderate to good yields. This catalytic approach represents a step-economic and convenient strategy for the difunctionalization of quinones. A plausible reaction pathway has been proposed based on a series of control experiments.
Key words
silver catalysis - one-pot - difunctionalization - quinones - indole - functionalized p-iminoquinones derivativesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1719929.
- Supporting Information
Publication History
Received: 02 April 2022
Accepted after revision: 08 May 2022
Article published online:
09 June 2022
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