Solvent-Free Tandem Reaction of P(O)–OH and an Epichlorohydrocarbon for Controllable O-Alkylation through a Ring-Opening and Annulation Process

Abstract

We report an efficient additive- and solvent-free O-alkylation of P(O)–OH compounds with epichlorohydrocarbons for the synthesis of epoxy-group-containing phosphinates. The transformation proceeds through a tandem reaction involving ring-opening and annulation processes. The ring-opened products and dechlorinated products can be obtained selectively by controlling the reaction conditions. This protocol is expected to be useful in industry because it is readily scaled up to a gram level and involves simple posttreatment.

Key words

solvent-free reaction - alkylation - epichlorohydrocarbons - phosphonic acids - tandem reaction - epoxy phosphinates

Publication History

Received: 05 February 2023

Accepted after revision: 11 April 2023

Article published online:
26 April 2023

• References and Notes

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