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Synlett 1991; 1991(9): 654-656
DOI: 10.1055/s-1991-20830
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Synthesis of N-[1-(2-Thienyl)cyclohexyl]piperidine (TCP) Based Irreversible Alkylators of the Phenylcyclidine (PCP) Recognition Site

Alan P. Kozikowski* , Abdul H. Fauq, Werner Tückmantel, Stefano O. Casalotti, Karl E. Krueger
  • *Neurochemistry Research, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
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Publikationsdatum:
07. März 2002 (online)

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Four new thienylcyclohexylamines {N-[1-(4-isothiocyanato/isoselenocyanato-2-thienyl)cyclohexyl]piperidine and 2-[1-(ethylaminocyclohexyl)-4-isothiocyanato/isoselenocyanatothiophene) have been synthesized and examined for their ability to alkylate the MK-801/PCP recognition sites associated with the N-methyl-D-aspartate receptor-ion channel complex.

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