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Synlett 1991; 1991(9): 639-641
DOI: 10.1055/s-1991-22018
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A Simple Synthesis of Ethynyl Substituted Phenylacetonitrile Derivatives by Phase-Transfer Catalysis (PTC)1

Andrzej Jończyk* , Tomasz Kuliński, Maciej Czupryniak, Paweł Balcerzak
  • *Department of Chemistry, Technical University (Politechnika), Koszykowa 75, PL-00-662 Warsaw, Poland
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Publikationsdatum:
07. März 2002 (online)

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Reaction of phenylacetonitrile derivatives 1 with vinylidene chloride (2) in the presence of 50% aqueous sodium hydroxide and tetrabutylammonium hydrogen sulfate (TBAHS) as a catalyst (phase-transfer catalysis, PTC) gives 2-substituted 2-ethynyl-2-phenylacetonitriles 3 in high yield. An addition-elimination route with the intermediacy of chloroacetylene is proposed

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