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Synthesis 1991; 1991(4): 306-308
DOI: 10.1055/s-1991-26451
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Aluminum Chloride Mediated Aminolysis of Lactones: A General Method for the Preparation of ω-Hydroxyalkylamides

Patrick Lesimple* , Dennis C. H. Bigg
  • *Centre de Recherche Pierre Fabre, 17 avenue Jean-Moulin, F-81106 Castres, France
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Publikationsdatum:
29. April 2002 (online)

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Medium-ring lactones react cleanly with primary and secondary aliphatic or aromatic amines in the presence of aluminum chloride at room temperature to afford ω-hydroxyalkylamides in high yield.

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