The N-tert-Butylcarbamoyl Directed Metalation Group for the Regiospecific Synthesis of 2-Substituted Pyrroles and Indoles

M. Gharpure; A. Stoller; F. Bellamy; G. Firnau; V. Snieckus

doi:10.1055/s-1991-28395

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Synthesis 1991; 1991(12): 1079-1082
DOI: 10.1055/s-1991-28395

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The N-tert-Butylcarbamoyl Directed Metalation Group for the Regiospecific Synthesis of 2-Substituted Pyrroles and Indoles

M. Gharpure^* , A. Stoller, F. Bellamy, G. Firnau, V. Snieckus

^*Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada

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Publication Date:
29 April 2002 (online)

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The N-tert-butylcarbamoyl serves as a useful, readily removable (LiOH/MeOH/THF) new directed metalation group for the synthesis of 2-substituted pyrroles and indoles.

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