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Synlett 1994; 1994(1): 69-70
DOI: 10.1055/s-1994-22742
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Kinetic Resolution of Oxiranes by Use of Chiral Lewis Acid Catalysts

M. Brunner* , L. Mußmann, D. Vogt
  • *Institute of Technical Chemistry and Petrolchemistry, RWTH Aachen, Templergraben 55, 52056 Aachen, FRG
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Publication Date:
22 March 2002 (online)

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The kinetic resolution of oxiranes by use of chiral Lewis acid catalysts is described. Improved stereoselectivities are observed in the nucleophilic ring opening of oxiranes with secondary amines. For the first time the enantioselective insertion of CO2 into the oxirane ring forming enantiomerically enriched 1,3-dioxolanones was achieved applying chirally modified Zr- and Ti-complexes.