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Synlett 1994; 1994(6): 417-419
DOI: 10.1055/s-1994-22871
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A Synthesis of Salinomycin. Part 2. Synthesis of the Dispiroacetal Core Unit via Oxidative Rearrangement of an Acyl Furan

Richard C. D. Brown* , Philip J. Kocieński
  • *Department of Chemistry, The University, Southampton, SO9 5NH, U.K.
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Publication Date:
18 September 2002 (online)

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A synthesis of the polyether antibiotic Salinomycin is completed by the union of the C11-C20 furan fragment 2, the C21-C30 lactone fragment 3 , and the C1-C9 tetrahydropyran fragment 14. A key step in the sequence is the oxidative rearrangement of a 2-acyl furan to the 1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene core unit.

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