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Synlett 1995; 1995(4): 347-348
DOI: 10.1055/s-1995-4970
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Asymmetric Hydrosilylation of Keto Esters Catalyzed by a Rhodium Complex with Trans-Chelating Chiral Diphosphine EtTRAP

Masaya Sawamura, Ryoichi Kuwano, Junya Shirai, Yoshihiko Ito*
  • *Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-01, Japan
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Publication Date:
31 December 2000 (online)

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Asymmetric hydrosilylation of α-, β-, and γ-keto esters with diphenylsilane in the presence of 1 mol% of a rhodium catalyst containing trans-chelating chiral phosphine ligand EtTRAP gave optically active alcohols with enantiomeric excesses ranging between 32-93%.

catalytic asymmetric synthesis - hydrosilylation - chiral phosphine - trans-chelating ligand - TRAP

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