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Synlett 1997; 1997(11): 1239-1240
DOI: 10.1055/s-1997-1002
DOI: 10.1055/s-1997-1002
letter
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Reversal of Anti to Syn Diastereoselectivity in Crotyltitanation Reaction
Further Information
Publication History
Publication Date:
31 December 2000 (online)
η3-2-Methylcrotyl(tiglyl)titanocene reacts with aldehydes to afford anti homoallylic alcohols when the reaction is carried out in THF, and preferentially syn products when the solvent is HMPA/THF=3:1. This simple control of anti versus syn diastereoselectivity expands considerably the synthetic uses of the crotyltitanation reaction.
η3-crotyltitanium complexes - homoallylic alcohols - anti vs syn diastereoselectivity