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Synlett 1997; 1997(3): 327-328
DOI: 10.1055/s-1997-760
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Iodine-Zinc Exchange Reactions Mediated by i-Pr2Zn. A New Preparation of Secondary Zinc Reagents

Laurent Micouin, Paul Knochel*
  • *Fachbereich Chemie der Philipps-Universität Marburg, Hans-Meerwein-Straße, D-35032 Marbug, Germany, Fax: 049-6421-282189; email: Knochel@ps1515.chemie.uni-marburg.de
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Publication Date:
31 December 2000 (online)

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By treatment with i-Pr2Zn, functionalized secondary alkyl iodides undergo a smooth iodine-zinc exchange reaction leading to polyfunctional secondary dialkylzinc derivatives. Remarkably, i-Pr2Zn generated in situ from i-PrMgBr and ZnBr2 undergoes this exchange reaction almost 200 times faster than salt free i-Pr2Zn and constitutes a practical source of i-Pr2Zn for the performance of exchange reactions.

diisopropylzinc - iodine-zinc exchange - magnesium catalysis - secondary zinc reagents - zinc-copper reagents

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