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Synlett 1998; 1998(8): 861-864
DOI: 10.1055/s-1998-1794
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Synthesis of Epothilones: Stereoselective Routes to Epothilone B

Dieter Schinzer* , Armin Bauer, Jennifer Schieber
  • *Chemisches Institut der Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, D-39106 Magdeburg, Germany; Fax + 49-391-67-12223; E-mail: Dieter.Schinzer@chemie.uni-magdeburg.de
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Publication History

Publication Date:
31 December 2000 (online)

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In connection with our studies of the total syntheses of epothilones we report our efforts on the syntheses of epothilone B using a macro-lactonization and a metathesis approach. Key reaction for the solution of the acyclic stereoselection is a stereoselective aldol reaction.

epothilones - natural products - anti-tumor-activity - aldol reaction - macro-lactonization - metathesis

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