Planta Med 2000; 66(3): 279-281
DOI: 10.1055/s-2000-14894
Letter

Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Coumarins from Decatropis bicolor on TPA Ear Mice Model

Aída N. García-Argáez1 , Teresa O. Ramírez Apan2 , Hortensia Parra Delgado2 , Guillermo Velázquez2 , Mariano Martínez-Vázquez2
  • 1 Laboratorio de Química, Facultad de Ciencias, Universidad Nacional Autónoma de México, México
  • 2 Instituto de Química, Universidad Nacional Autónoma de México, México
  • 3 National Research Institute of Chinese Medicine, Taipei City, Taiwan, R.O.C.
Further Information

Publication History

June 16, 1999

July 11, 1999

Publication Date:
31 December 2000 (online)

Abstract

From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1 - 6 were examined against the ear edema in mice produced by TPA. The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.