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Synlett 2000; 2000(12): 1773-1774
DOI: 10.1055/s-2000-8670
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Simple Synthesis of 2-Substituted Tetrahydrofuran-3-carbonitriles

Mieczysław Ma;cogon;kosza* , Jacek Przyborowski, Rafał Klajn, Andrzej Kwast
  • *Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, PL. 01-224 Warsaw, Poland; Fax +48(22)632 66 81; E-mail: icho-s@icho.edu.pl
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Publication Date:
31 December 2000 (online)

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Liquid/liquid Phase Transfer Catalysis (PTC) reaction of 4-chlorobutyronitrile with nonenolisable aldehydes leads via an addition-cyclisation reaction sequence to derivatives of tetrahydrofuran-3-carbonitrile.

phase-transfer catalysis - aldehydes - nitriles - cyclizations - tetrahydrofurans

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